Details
Shortpeptidescontainingtwodisulfidebridgescanforminterconvert
IBLetopoisomerswiththesamedisulfideconnectivity.Incaseofuroguanylin(UGN),botharerelativelystableandcanbeseparated,andinterconversionisslow.Thetopoisomersdifferin
BIOLOGicalactivity:TheUGNAtopomerpotentlyactivatestheguanylatecyclaseCreceptorfoundprimarilyintheintestine.TheBtopomerisaveryweakago
NISTofthisreceptor.Mossetal.couldshowthatUGNBhaspotentnatriureticactivityinthekidney.
ItemNumber4059285
OneLetterCodeNDDCELCVNVACTGCL
SynonymsUGNTopoisomerB(human)
MolecularFormulaC₆₄H₁₀₂N₁₈O₂₆S₄
RelativeMolecularMass1667.88
SourceSynthetic
StorageConditions-20±5°C
AreasofInterestGastrointestinalResearch
ObesityResearch
Productcitations
N.G.Mossetal.,Hypertension,53,867(2009)
N.Chinoetal.,FEBSLett.,421,27(1998)
U.C.Marxetal.,J.Pept.Res.,52,229(1998)