Details
ThelipopeptideFSL-1,synthesizedonthebasisoftheN-terminalstructureofaM.salivariumlipoprotein,iscapableofinducingthecellsurfaceexpressionofICAM-1inhumangingivalfibroblasts.Itfur
Thermorerevealedanactivitytoinduceproductionofmonocytechemoattractantprotein1,interleukin-6(IL-6),andIL-8.FSL-1alsoactivatedmacrophagestoproducetumornecrosisfactoralpha.Overall,resultsbyOkusawaandcoworkerssuggestthatthediacylglycerylandthepeptideportionsofFSL-1areindispensablefortheexpressionof
BIOLOGicalactivitiesandfortherecognitionbyToll-likereceptors2and6.Furthermore,thesameauthorsconcludethattherecognitionofFSL-1byToll-likereceptors2and6apparentlyishydrophobic.
ItemNumber4099727
OneLetterCodePam₂CGDPKHPKSFDYKDDDDK
SynonymsFibroblastStimulatingLipopeptide1FLAG-tag
MolecularFormulaC₁₂₅H₁₉₈N₂₄O₃₇S
RelativeMolecularMass2661.15
SourceSynthetic
StorageConditions-20±5°C
AreasofInterestImmunomodulatingAgents
Productcitations
T.Okusawa,Infect.Immun.,72,1657(2004)